Seminário: Dynamics of a CD4 + T cell immune response model and calibration to LCMV infection data

In this talk, I will present an ordinary differential equation (ODE) model of immune response dynamics describing the behaviour of CD4 + T cells, regulatory T cells (Tregs) and interleukine-2 cytokine (IL-2) density where regulatory T cells inhibit interleukine-2 secretion. I will succinctly describe some qualitative features of the model such as time evolution, equilibria and bifurcations. I will then fit the model to data reporting the CD4 + T cell numbers from the 28 days following the infection of mice with lymphocytic choriomeningitis virus (LCMV). The data consist of two time series of the Tcell responses to the gp61 and NP309 epitopes of the disease. We observed the proliferation of T cells and, to a lower extent, Tregs during the immune activation phase following infection and subsequently, during the contraction phase, a smooth transition from faster to slower death rates. In this way we have that the ODE model was able to be calibrated thus providing a quantitative description of the data.

Orador Convidado:

Prof. Filipe Martins (Department of Mathematics, Universidade do Porto and LIAAD-INESC)

Resumo:
Em anexo.

Em 20.11.2019
14:00 | CLAV-Anfiteatro 4
Anexos